MOTS-c

MOTS-c 10mg | Mitochondrial-Derived Peptide | ≥99% Purity (HPLC)

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the 12S rRNA region of the mitochondrial genome. This unique peptide acts as a retrograde signaling molecule that translocates to the nucleus under metabolic stress to regulate gene expression, enhance insulin sensitivity, and promote metabolic homeostasis.

Research investigations have demonstrated MOTS-c’s ability to:

• Improve insulin sensitivity and glucose uptake in skeletal muscle
• Enhance mitochondrial function and biogenesis
• Promote fat oxidation and reduce fat accumulation
• Protect against age-related metabolic decline
• Exert anti-inflammatory effects and improve exercise capacity
• Regulate folate and purine metabolism pathways
• Support cardiovascular health in models of metabolic dysfunction

MOTS-c is of major interest in aging, metabolic syndrome, type 2 diabetes, and mitochondrial biology research due to its role as a key regulator of nuclear-mitochondrial communication and energy metabolism.

For Research Use Only. Not for human consumption, diagnostic, therapeutic, or veterinary purposes. Strictly intended for in vitro laboratory research by qualified professionals.

Specifications:

• Sequence: MRWQEMGYIFYPRKLR
• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2174.6 Da
• Appearance: White lyophilized powder
• Purity: ≥99% (HPLC)
• Solubility: Water-soluble
• Storage: Lyophilized at -20°C; reconstituted at 2–8°C short-term. Protect from light and moisture.

Common Research Areas: Mitochondrial signaling • Insulin resistance • Metabolic homeostasis • Aging mechanisms • Exercise mimetics • Type 2 diabetes models • Fat metabolism • Nuclear gene regulation